17 Dec What is Glutathione?
What is Glutathione?
Glutathione is an extremely powerful antioxidant with numerous applications within the realms of health and nutrition. Its antioxidant and detoxifying properties safeguard cells from damage caused by reactive oxygen and heavy metals. Because of its essential role in protecting the human body, it has earned the nickname “The Mother of All Antioxidant”. For years doctors, had treated their patients with glutathione to relieve ailments ranging from liver disease to cancer. Evidence suggests that glutathione is produced within every cell of the body, but the liver—our main detoxifying organ—produces glutathione for export to other tissues. Knowing the best ways to optimize glutathione levels in tissues and blood is important. Glutathione levels within cells need to be higher than those outside of cells. Nevertheless, the glutathione levels in the fluids surrounding cells are important because they protect the cell membranes.
Doctors and patients begin to notice an interesting side effect; patients receiving glutathione looks brighter and more radiant. Dark sallow skin lightens up giving a healthy glow. Glutathione is now the forefront of skin lightening, esthetics due to its virtually non-existence risk of side effects and astonishing natural results.
Glutathione for Skin Whitening
Glutathione skin whitening works by interrupting melanin synthesis. Melanin is the pigment that gives the skin its color, so by suppressing it from developing, glutathione whitening rejuvenates the skin back to its purest, fairest tone. It is clinically proven to reduce dark spots and whiten skin by inhibiting melanin synthesis. One’s health is often said to be reflected by the condition of his or her skin and that is notably true when it comes to this method of skin whitening. By boosting overall health Glutathione benefits the skin. As an antioxidant, it neutralizes and eliminates free radicals that damage the skin at the cellular level that cause aging and discoloration.
‘The Mother of All Antioxidant’
Glutathione acts on a number of biological pathways in the skin. Its primary purpose is protection from skin’s greatest enemy oxidation. By acting as an antioxidant, glutathione can reduce skin damage from acne or sun exposures before it creates unsightly dark spots.
This is the part of the glutathione cycle, a perpetual cycle in which active glutathione is expended and restored to neutralize free radicals and other damaging oxidative chemicals.
The two enzymes within the glutathione cycle are glutathione peroxidase and glutathione reductase. Glutathione peroxidase allows reduced glutathione efficiently neutralize free radicals and peroxides. At the end of this reaction, glutathione is left in it inactive, oxidized, form. Oxidized glutathione is reduced back to its active state by glutathione reductase. The enzymatic regeneration of active glutathione allows for it to be highly effective even against chronic stressors like sun exposure.
A 2010 publication by Reuters et al, details the close link between these oxidative stresses with chronic inflammation and, ultimately, diseases such as cancer and diabetes. Oxidative stress activates a number of pro-inflammatory mediators, notably, NF-KB and PPAR-y, which cause the expression of inflammatory genes.
Melanin and Tyrosinase
Most people are already familiar with melanin, the pigment responsible for brown and yellow skin tones. It is born in the melanocytes, deep in the epidermis, and travels to the outer epidermis where it is expressed as a darkened skin tone. But, the real driving force of skin darkening is the enzyme tyrosinase. Tyrosinase catalyzes the formation of melanin during these separate stages of synthesis. Therefore, in the resistance of skin darkening, tyrosinase inhibition is the key.
Many molecules have been found to possess a tyrosinase inhibiting effect. Unsurprisingly, glutathione a powerful inhibitor. This may be due to glutathione’s ability to prevent a chain reaction in which reactive oxygen species induce tyrosinase.